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The precise ways that alcohol affects the brain and thereby behavior are not fully understood. Recent research has indicated that it exerts major effects on the structure and function of nerve cell membranes. These changes may be transient with acute alcohol intake or persist with chronic use. They probably play a major role in relation to the behavior associated with acute intoxication, and also account for the phenomena of tolerance and withdrawal.

In addition to its impact upon nerve cell membranes, alcohol also probably significantly affects the production and activity of a number of neurotransmitters, which convey messages from one nerve cell to another, as well as the receptors with which they interact. Possibly there may be inherited differences in the way alcohol is metabolized or influences the central nervous system (CNS). Such differences could be the biochemical basis for a genetic predisposition to alcoholism, which may be a significant factor in as many as 50% of all cases.

Without question, the CNS, particularly the brain, is the organ most sensitive to the presence of alcohol. This sensitivity is what being high, drunk, or intoxicated is all about. The intensity of the effect is directly related to the concentration of alcohol in the blood. The drug alcohol is a CNS depressant. It interferes with or lowers the activity of the brain. Not all parts of the brain are uniformly affected. If they were, the same amount required to release inhibitions would also be lethal by simultaneously hitting the parts controlling breathing.

Meanwhile, watch, or recall, someone becoming intoxicated and see the progression of effects. The following examples refer to typical CNS effects in men.

One drink. (The "drinks" here are a little under 1/2 ounce of pure alcohol, the equivalent of a 12-ounce beer or an ounce of 86-proof whiskey. Many generous hosts and hostesses mix drinks with more than 1 ounce of booze. So, as you read on, don't shrug off the "ten-drink" section as an impossibility. Five generous ones could easily have as much alcohol!) With one drink, the drinker will be a bit more relaxed, possibly loosened up a little. Unless he chugged it rapidly, thus getting a rapid rise in blood alcohol, his behavior will be little changed. Being of average height, weighing 160 pounds, by the end of an hour his blood alcohol level will be .02. (The actual measurement is grams %, or grams/100 milliliters. For example, 0.02 gr% = 200 mg%.) One hour later all traces of alcohol will be gone.

Two and a half drinks. With two and a half drinks in an hour's time, your party-goer will have a .05 blood alcohol level. He's high. The "newer" parts of the brain, those controlling judgment, have been affected. That our friend has been drinking is apparent. He may be loud, boisterous, making passes. Disinhibited, he is saying and doing things he might usuallyy censor. These are the effects that mistakenly cause people to think of alcohol as a stimulant. The system isn't really hyped up. Rather the inhibitions have been suspended, due to the depression by alcohol of the parts of the brain that normally give rise to them. At this time our friend is entering the danger zone for driving. With two and a half drinks in an hour, 2.5 hours will be required to completely metabolize the alcohol.

Five drinks. With five drinks in an hour, there is no question you have a drunk on your hands. The law would agree. A blood alcohol level of .10 is sufficient in most states to convict of DWI. By this time judgment is nil. "Off coursh I can drive!" In addition to the parts of the brain controlling judgment, the centers controlling muscle coordination are depressed. There's a stagger to the walk and a slur to the speech. Even though the loss of dexterity and reaction time can be measured, the drinker, now with altered perception and judgment, will claim he has never functioned better. Five hours will be required for all traces of alcohol to disappear from the system.

Ten drinks. This quantity of alcohol in the system yields a blood alcohol content of .20. More of the brain than just the judgment, perceptual and motor centers are affected. Emotions are probably very erratic—from laughter to tears to rage. Even if your guest could remember he had a coat—which he probably can't due to memory impairment—he'd never be able to put it on. Ten hours will be required for all the alcohol to be metabolized. Six hours, and he'll still be legally drunk.

One pint of whiskey. With this amount of booze, the drinker is stuporous. Though not passed out, nothing the senses take in actually registers. Judgment is gone, coordination wiped out, and sensory perception almost nil. With the liver handling 1 ounce of alcohol per hour, it will be 16 hours, well into tomorrow, before all the alcohol is gone.

One and one-fourth pints of whiskey. At this point, the person is in a coma and dangerously close to death. The vital brain centers, which send out instructions to the heart and breathing apparatus, are partially anesthetized. At a blood alcohol level of .4 to .5, a person is in a coma; at .6 to .7, death occurs.